Knox, who continues to recover from spinal fusion surgery, could miss the entire 2012 campaign. After the six-week window, the Bears would have three weeks to bring him back to practice or shut him down for the remainder of the season.
Knox speed on the outside might be missed, but the Bears compensated by landing two big receivers in three-time Pro Bowler Brandon Marshall and rookie Alshon Jeffery. Devin Hester will have to be the speedy, downfield threat Knox was when healthy.
The Bears also officially placed rookie safety Brandon Hardin on injured reserve with a neck injury and started announcing cuts. Rookie quarterback Matt Blanchard was waived, leaving the Bears with three quarterbacks.
The team also terminated the contract of vested veteran defensive tackle John McCargo; waived linebacker K.C. Asiodu, fullback Harvey Unga, safety Trevor Coston, receivers Terriun Crump and Chris Summers and defensive ends Thaddeus Gibson and Derek Walker; and waived/injured linebacker Adrien Cole and guard Nick Pieschel.
With the moves, the Bears' roster now stands at 75, which is where it had to before Monday's deadline. It must be trimmed to 53 by Friday.